解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Remodeling or deregulation of the calcium signaling pathway is a relevant hallmark of cancer including cutaneous melanoma (CM). In this study, using data from a published genome-wide association study (GWAS) from The University of Texas M.D. Anderson Cancer Center, we assessed the role of 41,377 common single-nucleoti...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgy188
更新日期:2019-04-29 00:00:00
abstract::Trabectedin is a marine-derived antineoplastic drug. Besides targeting the cancer cells, trabectedin has a peculiar activity on the tumor microenvironment with marked effects on the vasculature and the immune response. Because a favorable microenvironment is a key factor in the progression of cutaneous melanoma, we hy...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgy177
更新日期:2019-04-29 00:00:00
abstract::Polyphenols have shown promising bioactivity in experimental in vitro and in vivo models for cancer chemoprevention. However, consumed orally, they are often transformed by gut microbes into new active principles with so far incompletely deciphered molecular mechanisms. Here, enterolacton, S-equol and urolithin A as r...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgy158
更新日期:2019-03-12 00:00:00
abstract::Glioblastoma (GBM) is amongst the most aggressive brain tumors with a dismal prognosis. Despite significant advances in the current multimodality therapy including surgery, postoperative radiotherapy (RT) and temozolomide (TMZ)-based concomitant and adjuvant chemotherapy (CT), tumor recurrence is nearly universal with...
journal_title:Carcinogenesis
pub_type: 杂志文章,评审
doi:10.1093/carcin/bgy171
更新日期:2019-03-12 00:00:00
abstract::Cisplatin alone or in combination with 5FU (5-fluorouracil) and docetaxel (TPF) are common regimen chemotherapeutics for treatment of advanced oral squamous cell carcinoma (OSCC). Despite the initial positive response, several patients experience relapse due to chemoresistance. The potential role of Bcl-2 antiapoptoti...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgy135
更新日期:2019-03-12 00:00:00
abstract::2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is formed in cooked meats and may be linked to dietary-associated colorectal, prostate and mammary cancers. Genotoxic N-oxidized metabolites of PhIP react with the Cys34 of albumin (Alb) to form a sulfinamide adduct, a biomarker of the biologically effective dose....
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgy125
更新日期:2018-12-31 00:00:00
abstract::Liver metastases develop in more than half of the patients with colorectal cancer (CRC) and are associated with a poor prognosis. The factors influencing liver metastasis of CRC are poorly characterized, but this information is urgently needed. We have now discovered that small extracellular vesicles (sEVs; exosomes) ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgy115
更新日期:2018-12-13 00:00:00
abstract::The role of O-GlcNAc transferase (OGT) in gene regulation and tumor invasion is poorly understood. Here, we have identified several previously undiscovered OGT-interacting proteins, including the PRMT5/WDR77 complex, the PRC2 complex, the ten-eleven translocation (TET) family, the CRL4B complex and the nucleosome remo...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgy097
更新日期:2018-10-08 00:00:00
abstract::Breast cancer is a leading cause of cancer-related mortality in women. Triple-negative breast cancer (TNBC; HER2-, ER-/PR-) is an aggressive subtype prone to drug resistance and metastasis, which is characterized by high intratumor microvascular density (iMVD) resulting from angiogenesis. However, the mechanisms contr...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgy090
更新日期:2018-10-08 00:00:00
abstract::On the basis of preliminary in vitro experience, we assessed whether an enriched nutritional formulation with estrogen receptor (ER)-beta agonist and anti-inflammatory properties may prevent inflammation-associated colorectal cancer (CRC) in an animal model. Study sample enclosed 110 C57BL/6J male mice. Forty underwen...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgy104
更新日期:2018-10-08 00:00:00
abstract::The NF2 gene encodes the tumor and metastasis suppressor protein Merlin. Merlin exerts its tumor suppressive role by inhibiting proliferation and inducing contact-growth inhibition and apoptosis. In the current investigation, we determined that loss of Merlin in breast cancer tissues is concordant with the loss of the...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgy078
更新日期:2018-09-21 00:00:00
abstract::Estrogen plays an important role in breast cancer development. While the mechanism of the estrogen effects is not fully elucidated, one possible route is by increasing the stem cell-like properties in the tumors. Tocopherols are known to reduce breast cancer development and progression. The aim of the present study is...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgy071
更新日期:2018-07-30 00:00:00
abstract::4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is the most abundant and carcinogenic tobacco-specific nitrosamine in tobacco and tobacco smoke. The major metabolic pathway for NNK is carbonyl reduction to form the (R) and (S) enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) which, like NNK, is...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgy065
更新日期:2018-07-30 00:00:00
abstract::Genomic alterations affecting components of the mechanistic target of rapamycin (mTOR) pathway are found rather frequently in cancers, suggesting that aberrant pathway activity is implicated in oncogenesis of different tumor types. mTOR functions as the core catalytic kinase of two distinct complexes, mTOR complex 1 (...
journal_title:Carcinogenesis
pub_type: 杂志文章,评审
doi:10.1093/carcin/bgy086
更新日期:2018-07-30 00:00:00
abstract::Prostate cancer (PCa) is a clinically and molecularly heterogeneous disease, with variation in outcomes only partially predicted by grade and stage. Additional tools to distinguish indolent from aggressive disease are needed. Phenotypic characteristics of stemness correlate with poor cancer prognosis. Given this corre...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgy062
更新日期:2018-07-03 00:00:00
abstract::Super elongation complex (SEC) controls gene transcription by releasing Pol II from pausing. Previous studies have shown that dysfunction of SEC was associated with multiple human cancers, such as leukemia and breast cancer. However, the role of SEC in head and neck squamous cell carcinoma (HNSCC) development remains ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgy046
更新日期:2018-07-03 00:00:00
abstract::Although the anticancer properties of oligomeric proanthocyanidins (OPCs) from grape seeds have been well recognized, the molecular mechanisms by which they exert anticancer effects are poorly understood. In this study, through comprehensive RNA-sequencing-based gene expression profiling in multiple colorectal cancer ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgy034
更新日期:2018-05-28 00:00:00
abstract::Amino acids (AAs) are biologically important nutrient compounds necessary for the survival of any cell. Of the 20 AAs, cancer cells depend on the uptake of several extracellular AAs for survival. However, which extracellular AA is indispensable for the survival of cancer cells and the molecular mechanism involved have...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgy033
更新日期:2018-05-28 00:00:00
abstract::Inflammation is highly associated with colon carcinogenesis. Epigenetic mechanisms could play an important role in the initiation and progression of colon cancer. Curcumin, a dietary phytochemical, shows promising effects in suppressing colitis-associated colon cancer in azoxymethane-dextran sulfate sodium (AOM-DSS) m...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgy043
更新日期:2018-05-03 00:00:00
abstract::Colorectal cancer (CRC) is the fourth leading cause of cancer mortality worldwide. Genome-wide association studies (GWAS) identified more than 50 CRC loci. However, most of the previous studies were conducted in European population, and host genetic factors among Japanese population are largely remained to be identifi...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgy026
更新日期:2018-05-03 00:00:00
abstract::Targeting tumor-initiating, drug-resistant populations of cancer stem cells (CSC) with phytochemicals is a novel paradigm for cancer prevention and treatment. We herein employed a phenotypic drug discovery approach coupled to mechanism-of-action profiling and target deconvolution to identify phenolic components of ext...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgy023
更新日期:2018-04-05 00:00:00
abstract::Elevated Bcl-xL expression in cancer cells contributes to doxorubicin (DOX) resistance, leading to failure in chemotherapy. In addition, the clinical use of high-dose doxorubicin (DOX) in cancer therapy has been limited by issues with cardiotoxicity and hepatotoxicity. Here, we show that co-treatment with pyrrolidine ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgy003
更新日期:2018-03-08 00:00:00
abstract::Microsatellite instability (MSI) is present in ulcerative colitis (UC) and colitis-associated colorectal cancers (CAC). Certain factors released by polymorphonuclear cells (PMNs) may drive mucosal frameshift mutations resulting in MSI and cancer. Here, we applied a co-culture system with PMNs and colon epithelial cell...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgx118
更新日期:2018-02-09 00:00:00
abstract::Pancreatic cancer has remained refractory to treatment. In large part, this results from the lack of an animal model that mimics pancreatic cancer in man. We describe a novel experimental model of pancreatic cancer that shares the genetic background, histologic features and natural history of human mixed acinar-ductal...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgx119
更新日期:2018-02-09 00:00:00
abstract::Alteration in microRNAs (miRNAs) expression is a frequent finding in human cancers. In particular, widespread miRNAs down-regulation is a hallmark of malignant transformation. In the present report, we showed that the miR-128-3p, which is up-regulated in lung cancer tissues, has Drosha and Dicer, two key enzymes of mi...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgx134
更新日期:2018-02-09 00:00:00
abstract::Zuotin-related factor 1 (ZRF1) is a recently characterized epigenetic factor involved in transcriptional regulation and is highly overexpressed in several malignancies, but it is not known whether it plays a role in gastric cancer (GC). In this study, we investigated whether ZRF1 acts as a cancer-promoting gene throug...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgx139
更新日期:2018-02-09 00:00:00
abstract::Eukaryotic 3'-end formation is a critical step for mRNA maturation and involves a requisite cleavage and polyadenylation event downstream of a polyadenylation signal. Recent discoveries suggest that in nearly 70% of human genes, cleavage and polyadenylation can occur at multiple locations through a process known as al...
journal_title:Carcinogenesis
pub_type: 杂志文章,评审
doi:10.1093/carcin/bgx096
更新日期:2018-01-12 00:00:00
abstract::Celastrol is an anti-inflammatory natural triterpenoid, isolated from the herb Tripterygium wilfordii or thunder god vine. Here, we define mechanisms mediating anti-inflammatory activity of celastrol and demonstrate efficacy of a dietary celastrol supplement for chemoprevention of inflammation-driven carcinogenesis in...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgx115
更新日期:2018-01-12 00:00:00
abstract::Herbacetin is a flavonol compound that is found in plants such as flaxseed and ramose scouring rush herb, it possesses a strong antioxidant capacity, and exerts anticancer effects on colon and breast cancer. However, the effect of herbacetin on skin cancer has not been investigated. Herein, we identified herbacetin as...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgx082
更新日期:2017-10-26 00:00:00
abstract::Ovarian cancer (OC) has the highest mortality rate of all gynecological cancers, and most patients develop chemoresistance after first-line treatments. Despite recent advances, the 5-year relative survival is ~45% for all OC subtypes, and invasive epithelial OC has only a 17% survival rate when diagnosed at a late sta...
journal_title:Carcinogenesis
pub_type: 杂志文章,评审
doi:10.1093/carcin/bgx054
更新日期:2017-10-01 00:00:00
abstract::DNA double-strand break (DSB) repair is an important mechanism underlying chemotherapy resistance in human cancers. Dicer participates in DSB repair by facilitating homologous recombination. However, whether Dicer is involved in non-homologous end joining (NHEJ) remains unknown. Here, we addressed whether Dicer regula...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgx059
更新日期:2017-09-01 00:00:00
abstract::Alcohol is a major risk factor for oesophageal squamous cell carcinoma (OSCC), the most prevalent histological subtype of oesophageal cancer (OC) worldwide. The metabolism of alcohol is regulated by specific enzymes whose activity and expression is influenced by genetic polymorphisms. We conducted a systematic review ...
journal_title:Carcinogenesis
pub_type: 杂志文章,评审
doi:10.1093/carcin/bgx067
更新日期:2017-09-01 00:00:00
abstract::Arsenite is well established as a human carcinogen, but the molecular mechanisms leading to arsenite-induced carcinogenesis are complex and elusive. Accelerated glycolysis, a common process in tumor cells called the Warburg effect, is associated with various biological phenomena. However, the role of glycolysis induce...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgx034
更新日期:2017-06-01 00:00:00
abstract::The landscape of HPV infection in racial/ethnic subgroups of head and neck cancer (HNC) patients has not been evaluated carefully. In this study, a meta-analysis examined the prevalence of HPV in HNC patients of African ancestry. Additionally, a pooled analysis of subject-level data was also performed to investigate H...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgw203
更新日期:2017-02-01 00:00:00
abstract::Reprogrammed metabolism has been identified as an emerging hallmark in cancer cells. It has been demonstrated that fructose-1, 6-bisphosphatase 1 (FBP1) as a rate-limiting enzyme in gluconeogenesis plays critical roles in tumor initiation and progression in several cancer types. However, function of FBP1 in hepatocell...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgw109
更新日期:2017-02-01 00:00:00
abstract::Germline genetic variability might contribute, at least partially, to the survival of pancreatic ductal adenocarcinoma (PDAC) patients. Two recently performed genome-wide association studies (GWAS) on PDAC overall survival (OS) suggested (P < 10(-5)) the association between 30 genomic regions and PDAC OS. With the aim...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgw080
更新日期:2016-10-01 00:00:00
abstract::Cancer is a leading cause of death worldwide and environmental factors, including chemicals, have been suggested as major etiological incitements. Cancer statistics indicates that men get more cancer than women. However, differences in the known risk factors including life style or occupational exposure only offer par...
journal_title:Carcinogenesis
pub_type: 杂志文章,meta分析
doi:10.1093/carcin/bgw076
更新日期:2016-10-01 00:00:00
abstract::No previous study has examined the association between mitochondrial DNA copy number (mtCN) and skin cancer risk prospectively. We examined the associations between peripheral blood leukocytes mtCN level and the risks of skin cancers in a case-control study nested within the Nurses' Health Study of non-Hispanic White ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgw072
更新日期:2016-09-01 00:00:00
abstract::The H2-receptor antagonist, ranitidine, is among the most widely used pharmaceuticals to treat gastroesophageal reflux disease and peptic ulcers. While previous studies have demonstrated that amines can form N-nitrosamines when exposed to nitrite at stomach-relevant pH, N-nitrosamine formation from ranitidine, an amin...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgw034
更新日期:2016-06-01 00:00:00
abstract::Genome-wide association studies (GWAS) have identified 58 susceptibility alleles across 37 regions associated with the risk of colorectal cancer (CRC) with P < 5×10(-8) Most studies have been conducted in non-Hispanic whites and East Asians; however, the generalizability of these findings and the potential for ethnic-...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgw046
更新日期:2016-06-01 00:00:00